Estradiol, applied vaginally
Estradiol in a cream applied in the vagina, used for vaginal dryness, irritation and painful sex after menopause. Some is absorbed into the bloodstream.
Not for
- Anyone with undiagnosed abnormal genital bleeding.
- Anyone with a history of, or suspected, breast cancer, or another estrogen-dependent cancer.
- Anyone with active or past blood clots, or a clotting disorder.
- Anyone who is pregnant, or who may be pregnant.
Handling
- Hormone cream transfers by skin contact, including to a partner. Wash your hands after applying.
- This is a compounded strength, not one of the FDA-approved vaginal cream products, so how much is absorbed is less predictable.
Common effects
- Local irritation, itching or discharge.
- Headache and breast tenderness.
Serious effects
- The systemic risks in the boxed warning apply, because some estrogen is absorbed.
- Endometrial cancer, where the uterus is present and estrogen is used without adequate progestogen.
Get medical help if
- New, heavy or continuing vaginal bleeding.
- Sudden shortness of breath, chest pain, leg swelling or pain.
- Sudden weakness, numbness or trouble speaking.
Tell your provider
- Whether you still have a uterus.
- Any history of breast cancer, clots or stroke.
Sources
- Estradiol vaginal cream prescribing information. US Food and Drug Administration. FDA-approved labeling
- Estradiol tablets prescribing information, Boxed Warning. US Food and Drug Administration. FDA-approved labeling
- Compounding and the FDA: questions and answers. US Food and Drug Administration. FDA drug compounding guidance